| Autor: |
Walker, John M., Kazmierski, Wieslaw M., Perlow, Debra S., Freidinger, Roger M. |
| Zdroj: |
Peptidomimetics Protocols; 1999, p209-225, 17p |
| Abstrakt: |
Lactam-bridged dipeptides are useful tools for the introduction of conformational constraint in higher peptides. General methods have been devised for the synthesis of dipeptides having five-, six-, and seven-membered ring constraints (1,2). This chapter will focus on four synthetic paths from protected chiral a-amino acids to lactams that involve intramolecular alkylation, intermolecular alkylation, intramolecular acylation, and condensation with formaldehyde for a one carbon unit insertion. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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