| Autor: |
Jiang, Wen G., Dvorak, Harold F., Gold, Phil, Welch, Danny, Kobayashi, Hiroshi, Mansel, Robert E., Pantel, Klaus, Ablin, Richard J., Mason, Malcolm D., Hendrix, Mary J.C., Luo, Jun, Seftor, Elisabeth A., Sharma, Navesh, Heidger, Paul M., Cohen, Michael B., Bhatty, Robert, Chungthapong, Jirapat, Seftor, Richard E.B., Lubaroff, David |
| Zdroj: |
Metastasis of Prostate Cancer; 2007, p127-141, 15p |
| Abstrakt: |
Tumor cell plasticity poses a significant clinical challenge in that the fate and function of tumor cells can be elusive until a tumor mass is evident. An overview of key molecular events in prostate cancer, initiated by an epithelial-to-mesenchymal transition, highlights the cooperative interactions of diverse prostatic subpopulations within heterogeneous tumors. A remarkable example of plasticity is demonstrated by subpopulations of E-cadherin-positive and E-cadherin-negative tumor cells working in concert to form de novo vasculogenic-like networks while expressing vascular-associated genes, called vasculogenic mimicry, resulting in acquisition of the metastatic phenotype. A better understanding of the molecular mechanisms underlying prostate tumor cell plasticity may provide new prognostic markers for clinical diagnosis and novel therapeutic intervention strategies for disease management. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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