Modification of Human Bacterial Artificial Chromosome Clones for Functional Studies and Therapeutic Applications.

Autor: Walker, John M., Sgaramella, Vittorio, Eridani, Sandro, Orford, Michael R., Jamsai, Duangporn, McLenachan, Samuel, Ioannou, Panayiotis A.
Zdroj: Mammalian Artificial Chromosomes; 2004, p243-266, 24p
Abstrakt: With the completion of the sequencing phase of the Human Genome Project and the availability of fully sequenced clones containing intact functional loci from the various high-quality human P1- and F-plasmid derived/bacterial artificial chromosome (PAC/BAC) genomic libraries (1,2), it is becoming more convenient to study the expression and regulation of genes in their native genomic environment and to use such knowledge for therapeutic applications. [ABSTRACT FROM AUTHOR]
Databáze: Supplemental Index