Analyses of Glycopeptides and Glycoproteins by Liquid Chromatography-Mass Spectrometry and Liquid Chromatography-Tandem Mass Spectrometry.

Autor: Walker, John M., Aguilar, Marie-Isabel, Kawasaki, Nana, Ohta, Miyako, Itoh, Satsuki, Hayakawa, Takao
Zdroj: HPLC of Peptides & Proteins; 2004, p263-274, 12p
Abstrakt: A variety of recombinant glycoproteins, including erythropoietin (EPO), and tissue plasminogen activator have been developed as medical agents. The carbohydrate moieties are known to be implicated in the biological activity, metabolic fate, stability, and solubility of these compounds, and it is, therefore, important to analyze the structural features of carbohydrate moieties as well as polypeptide chains in glycoprotein products (1). [ABSTRACT FROM AUTHOR]
Databáze: Supplemental Index