| Autor: |
Walker, John M., D'Ambrosio, Daniele, Sinigaglia, Francesco, Fuentes, Maria Elena |
| Zdroj: |
Cell Migration in Inflammation & Immunity; 2003, p181-188, 8p |
| Abstrakt: |
Among the most important regulators of leukocyte migration are chemokines, a group of low-molecular-weight cytokines (8-10 kDa) that regulate cell infiltration and trafficking. They are responsible for the recruitment of leukocytes to sites of injury and inflammation and, more recently, have also been identified as major players in the homeostatic trafficking of cells to lymphoid tissues. They exert their action through seven-transmembrane G-protein-coupled receptors and trigger a cascade of signaling events including activation of phospholipase C and phosphoinositol 3 kinase γ and calcium mobilization (1). [ABSTRACT FROM AUTHOR] |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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