| Autor: |
Teicher, Beverly A., Singh, Gurmit, Rabbani, Shafaat A., Parry, Graham C., Doñate, Fernando, Plunkett, Marian L., Shaw, David E., Pirie-Shepherd, Steven, Mazar, Andrew P. |
| Zdroj: |
Bone Metastasis; 2005, p201-227, 27p |
| Abstrakt: |
Metastasis to bone is a major complication of advanced cancer and occurs in more than 400,000 cancer patients each year. Bone metastasis can arise from many different tumor types, including breast, prostate, lung, renal cell, thyroid, and bladder cancer, and in patients with melanoma and myeloma. The development of bone metastasis in cancer patients contributes significantly to the morbidity and mortality associated with the disease and leads to increased bone pain, increased bone fragility and fracture, and sometimes death. Metastatic tumor cells in the bone co-opt normal processes involved in bone resorption and bone formation and stimulate the formation of either osteolytic (dependent on the lytic, bone-resorptive activities of osteoclasts) or osteoblastic (dependent on the bone-forming activities of osteoblasts) metastatic lesions. Most tumor types form predominantly osteolytic lesions, with the exception of prostate cancer, which can lead to metastatic lesions of both the osteoblastic and the osteolytic phenotype. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Supplemental Index |
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