| Autor: |
Walker, John M., English, Lisa Bellavance, Choudhary, Seema, Morrow, Janet R. |
| Zdroj: |
Combinatorial Library; 2002, p215-225, 11p |
| Abstrakt: |
Combinatorial methods have been applied with a measure of success in the field of metal ion coordination chemistry (1-5). High-throughput screening methods have been used to facilitate the discovery of new catalysts and to design ligands for binding metal ions (6-9). Metal ion coordination complexes have been central to the development of dynamic combinatorial methods as well. Dynamic combinatorial methods utilize a library whose composition is con-trolled through reversible interactions with a target molecule (10,11). Metalligand bonds are often labile enough to undergo reversible bond formation under mild conditions, making metal ions ideal components for dynamic librar-ies. Such metal ion complexes are used in dynamic combinatorial libraries for the purpose of designing compounds with unusual shapes or recognition properties (12,13). [ABSTRACT FROM AUTHOR] |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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