| Autor: |
Ablin, Richard J., Mansel, Robert E., Fodstad, Oystein, Jiang, Wen G., Bracke, Marc E., De Maeseneer, Daan, Van Marck, Veerle, Derycke, Lara, Vanhoecke, Barbara, De Wever, Olivier, Depypere, Herman T. |
| Zdroj: |
Metastasis of Breast Cancer; 2007, p47-75, 29p |
| Abstrakt: |
Motility and invasion of breast cancer cells are the result of the concerted action of a number of cell activities: directional migration underpinned by the dynamic organisation of cytoskeletal components (actin micro-filaments and microtubules), establishment and disruption of cell-matrix and homotypic/heterotypic cell-cell adhesions, and extracellular proteolysis. Metastasis formation is not only related to cancer cell motility, but also necessitates the collaboration of other, coined "host" cells. Newly discovered ligand-receptor interactions between cancer cells and these host elements offer a molecular explanation for Paget's "seed and soil" hypothesis, and indicate new targets for possible anti-metastatic therapeutic agents [ABSTRACT FROM AUTHOR] |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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