| Autor: |
Kusano, Mitsuo, Shioda, Seiji, Soda, Teruko, Suzuki, Hiroshi, Kusuyama, Taro, Yokota, Yuya, Omori, Yasutoshi, Sato, Takatoshi, Tsunoda, Fumiyoshi, Shoji, Makoto, Iso, Yoshitaka, Koba, Shinji, Geshi, Eiichi, Katagiri, Takashi, Tomoyasu, Shigeru |
| Zdroj: |
New Frontiers in Regenerative Medicine; 2007, p95-100, 6p |
| Abstrakt: |
[Case Report] A 47-year-old man with Buerger's disease was admitted with complaints of progressive ulcer of left planta pedis and resting pain of the left leg. The ulcer was not healed under medical therapy nor lumbar sympathetic ganglion block, and angioplasty or bypass surgery was not applicable. All his toes showed cyanotic and left third and fifth toes were gangrene, as well as ulcer in left planta pedis. Angiography showed arterial occlusion in the crus and formation of corkscrew like changes. Although ankle-brachial index was kept in almost normal range, transcutaneous oxygen pressure (TcO2) was decreased. Leg pain was not relieved with medication and he could not walk for pain due to his ulcer. We performed bone-marrow mononuclear cell implantation to his inferior limbs to achieve therapeutic angiogenesis. After aspirating the bone marrow (600 ml) from the ileum, the bone-marrow mononuclear cells were sorted. The separated cells were implanted into the ischemic legs by intramuscular injection. Reduction of leg pain was observed as early as 3 days, and completely disappeared at rest after 4 weeks. Improvement of TcO2 was observed at 1 week, and the ulcer of planta pedis was almost healed 4 weeks after the therapy. [Conclusion] Bone-marrow mononuclear cell implantation is very effective in patients with Buerger's disease, even they have large severe ulcer. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
