| Autor: |
Foster, Samuel B., McIntosh, Kenneth, Thompson, Bruce, Lu, Ming, Yin, Wanrong, Rich, Kenneth C., Mendez, Hermann, Serchuck, Leslie K., Diaz, Clemente, Paul, Mary E., Shearer, William T. |
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| Zdroj: |
Journal of Allergy & Clinical Immunology; Jul2008, Vol. 122 Issue 1, p159-165, 7p |
| Abstrakt: |
Background: Immunoreconstitution of HIV+ patients after treatment with highly active antiretroviral therapy (HAART) appears to provoke inflammatory diseases. Objective: We sought to determine whether HIV+ children receiving HAART (HIV+ HAART+) have a higher incidence of asthma than HIV+ children not receiving HAART (HIV+ HAART−). Methods: Two thousand six hundred sixty-four children (193 HIV+ and 2471 HIV− children) born to HIV+ women were evaluated for the incidence and prevalence of asthma (ie, asthma medication use) and change of CD4+ T-cell percentage with time. Results: The HIV+ HAART+ children had higher CD4+ T-cell percentages, lower CD8+ T-cell percentages, and lower viral burdens than the HIV+ HAART− children (P ≤ .05 to P ≤ .01). The cumulative incidence of asthma medication use in HIV+ HAART+ children at 13.5 years increased to 33.5% versus 11.5% in HIV+ HAART− children (hazard ratio, 3.34; P = .01) and was equal to that in the HIV− children. In children born before the HAART era, the prevalence of asthma medication use for HIV+ HAART+ children at 11 years of age was 10.4% versus 3.8% for HIV+ HAART− children (odds ratio, 3.38; P = .02) and was equal to that of the HIV− children. The rate of change of CD4+ T cells around the time of first asthma medication for HIV+ HAART+ versus HIV+ HAART− children was 0.81%/y versus −1.43%/y (P = .01). Conclusion: The increased incidence of asthma in HIV+ HAART+ children might be driven by immunoreconstitution of CD4+ T cells. [Copyright &y& Elsevier] |
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