Dynamics of DNA and Portein-DNA Complexes Viewed Through Time-Domain Fluorescence.

Autor: Geddes, Chris D., Lakowicz, Joseph R., Nag, Nabanita, Ramreddy, T., Kombrabail, Mamata, Krishna Mohan, P. M., D'souza, Jacinta, Rao, B. J., Duportail, Guy, Mely, Yves, Krishnamoorthy, G.
Zdroj: Reviews in Fluorescence 2006; 2006, p311-340, 30p
Abstrakt: One of the recurring themes in modern biology, namely, dynamics along with structure forms the basis of function of biomolecular systems is getting increasing level of support from various experimental and molecular dynamics simulation techniques. In this chapter, the power of time-resolved fluorescence spectroscopy in bringing to light various intricate aspects of DNA dynamics and, in some cases, their correlation with function has been shown. We believe that this is a very fruitful approach in seeking explanations for complex activity o f DNA based systems especially in the light of the enormous level of structural information being gathered in recent times. [ABSTRACT FROM AUTHOR]
Databáze: Supplemental Index