| Autor: |
Lecea, Luis, Sutcliffe, J. Gregor, Wortley, Katherine E., Leibowitz, Sarah F. |
| Zdroj: |
Hypocretins; 2005, p307-314, 8p |
| Abstrakt: |
These results indicate that hypocretin/orexin neurons in the PFH are highly responsive to changes in circulating and dietary nutrients. They have similar properties to NPY/AgRP-expressing neurons in the ARC, in being stimulated by negative energy balance, such as after food deprivation, when glucose levels are declining and corticosterone and ghrelin levels are elevated. They are also similar to galanin-expressing neurons in the PVN, in being stimulated by dietary fat and circulating lipids and in exhibiting a natural rise during the first half of the circadian feeding cycle when fat ingestion normally increases. In states of both energy deficiency and elevated fat consumption, the hypocretin/orexin peptides may provide an important link between energy homeostasis and brain mechanisms coordinating sleep/wakefulness and motivated behaviors. Specifically, they may function to increase arousal and locomotor activity that facilitate food-seeking behavior under conditions of food deprivation, and they may also facilitate activity-based energy expenditure and hyperphagia under conditions of excess dietary fat intake. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
