| Autor: |
Conn, Michael, Kordon, Claude, Christen, Yves, Rivier, J., Gulyas, J., Erchegyi, J., Koerber, S. C., Grace, C. R. R., Riek, R., DiGruccio, M., Perrin, M., Rivier, C., Eltschinger, V., Waser, B., Cescato, R., Reubi, J. C., Vale, W. |
| Zdroj: |
Insights into Receptor Function & New Drug Development Targets; 2006, p117-138, 22p |
| Abstrakt: |
Strategies for the design of peptide agonists and antagonists of gonadotropin releasing hormone (GnRH, one ligand and one receptor) and of receptor-selective agonists and antagonists of somatostatin (SRIF, three ligands and five receptors) and corticotropin releasing factor (CRF, three ligands and two receptors) are described. These strategies include the use of unusual amino acids, a versatile scaffold based on aminoglycine (betidamino acids) and side chain as well as backbone conformational constraints. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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