| Autor: |
Li, Jonathan J., Li, Sara A., Llombart-Bosch, Antonio, Mai, Sabine, Guffei, Amanda, Fest, Thierry, Mushinski, J. Frederic |
| Zdroj: |
Hormonal Carcinogenesis IV; 2005, p87-97, 11p |
| Abstrakt: |
c-Myc is a versatile protein that has many different functions. With respect to genomic instability, it affects many endpoints that include gene amplification, translocation, deletions, insertions, long-range rearrangements, DNA breakage, and point mutations. This overall promotion of genomic instability suggests that c-Myc may have a central role in destabilizing the genome. We propose that c-Myc is a structural modifier of the genome and an important initiator and progressor molecule in neoplastic transformation. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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