| Autor: |
Gong Yi-ming, Xu Ming, Gu Zhang-yu |
| Zdroj: |
Shanghai Journal of Stomatology; Apr2008, Vol. 17 Issue 2, p121-124, 4p, 5 Charts |
| Abstrakt: |
PURPOSE: To investigate the prevalence of gingival overgrowth(GO) in a group of renal transplant recipients medicated with cyclosporine A (CsA) in comparison to those medicated with tacrolimus (Tcr). METHODS: 107 renal transplant recipients ( 85 CsA and 25 Tcr) were recruited into this study. Demographic, pharmacologic and periodontal data was recorded. The prevalence and severity of GO were compared between the two groups. The data was analyzed by SPSS13.0 software package for independent sample t test, &chi² test, Mann-Whitney U test and stepwise regression analysis. RESULTS: The prevalence of GO in the CsA group(49%)was significantly higher than that in the Tcr group(16%)(P < 0.05). The CsA group showed a higher mean GO score (30.3±15.5) compared with the Tcr group(17.5±9.6) (P<0.001).In addition, the patients with GO presented a significantly higher plaque index and papilla bleeding index than those without GO in two groups(P<0.05). CONCLUSION: The prevalence of GO is higher in renal transplant recipients taking CsA compared to Tcr. Plaque-induced gingival inflammation has a close relation with the severity of GO. Supported by The Youth Scientific Research Foundation of Fudan University- (Grant No.2007-205). [ABSTRACT FROM AUTHOR] |
| Databáze: |
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