| Autor: |
Morikawa, Yutaka, Kinoshita, Hiromi, Asahi, Masumi, Takasu, Akinori, Hirabayashi, Tadamichi |
| Předmět: |
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| Zdroj: |
Polymer Journal; 2008, Vol. 40 Issue 3, p217-222, 6p |
| Abstrakt: |
Novel amphiphilic and biodegradable gels composed of glucopyranoside, poly (ϵ-caprolactone) (PCL, n =25-63), and poly (ethylene glycol) (PEG, m = 3) were synthesized. Methyl 2,3-di-O-benzyl-α-D-glucopyranoside was used as an initiator for ring-opening polymerization (ROP) of ϵ-caprolactone (ϵ-CL). The primary hydroxyl group (6-OH) in the above sugar derivative acted chemoselectively as the initiator for living ROP of ϵ-CL, yielding sugar-headed PCL with various lengths of PCL-chains The polymerization temperature (60°C) is very important to suppress the competitive initiation reaction from the secondary hydroxyl group (C4-OH). In order to prepare the cross-linker, both α and ω-termini of PEO (n = 3 and 23) were converted to dicarboxylic chlorides, which actually acted as a coupling reagent for tailor-made amphiphilic biodegradable gel having a sequence of "Sugar-PCL-PEG-PCL-Sugar." [ABSTRACT FROM AUTHOR] |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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