Angiotensin 11-Induced Extracellular Signal-Regulated Kinase 1/2 Activation Is Mediated by Protein Kinase Cδ and Intracellular Calcium in Adult Rat Cardiac Fibroblasts.

Autor: Olson, Erik R., Shamhart, Patricia E., Naugle, Jennifer E., Meszaros, J. Gary
Zdroj: Hypertension (0194911X); Mar2008, Vol. 51 Issue 3, p704-711, 8p
Abstrakt: The article reports that angiotensin II-induced extracellular signal-regulated kinase 1/2 activation is mediated by protein kinase and intracellular calcium in adult rat cardiac fibroblasts. The author reveals that angiotensin II-induced proliferation of cardiac fibroblasts is a major contributing factor to the pathogenesis of cardiac fibrosis.
Databáze: Supplemental Index