Early pregnancy termination with intravaginally administered sodium chloride solution-moistened misoprostol tablets: historical comparison with mifepristone and oral misoprostol.

Autor:	Jain, John K., Meckstroth, Karen R., Jain, J K, Meckstroth, K R, Mishell, D R Jr
Předmět:	MIFEPRISTONE ABORTIFACIENTS ABORTION COMBINATION drug therapy COMPARATIVE studies LONGITUDINAL method RESEARCH methodology MEDICAL cooperation ORAL drug administration FIRST trimester of pregnancy RESEARCH SALT DRUG tablets VAGINAL medication EVALUATION research RANDOMIZED controlled trials TREATMENT effectiveness MISOPROSTOL
Zdroj:	American Journal of Obstetrics & Gynecology; Dec99, Vol. 181 Issue 6, p1386-1391, 6p, 2 Charts
Abstrakt:	Objective: The purpose of this study was to compare the abortifacient effect of intravaginally administered moistened misoprostol tablets with that of the combination regimen of mifepristone and oral misoprostol.Study Design: One hundred women at Results: In 88 of the 100 women in group 1 and 94 of the 100 women in group 2, abortion occurred and a surgical procedure was not required. Abortion rates were not influenced by gestational age in either group. Prostaglandin-related side effects of fever and chills, vomiting, diarrhea, and uterine pain were all significantly higher in group 1. Excessive uterine bleeding was uncommon in both groups, and no subjects received blood transfusions.Conclusion: The abortion rate with intravaginally administered moistened misoprostol tablets is similar to that with the combination of mifepristone and oral misoprostol. However, intravaginal administration of misoprostol is associated with significantly more prostaglandin-related side effects. [ABSTRACT FROM AUTHOR]
Databáze:	Supplemental Index
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