| Autor: |
Seble Kassaye, Esther Lee, Rami Kantor, Elizabeth Johnston, Mark Winters, Lynn Zijenah, Patrick Mateta, David Katzenstein |
| Zdroj: |
AIDS Research & Human Retroviruses; Aug2007, Vol. 23 Issue 8, p1055-1061, 7p |
| Abstrakt: |
Single-dose nevirapine (SD NVP) reduces intrapartum HIV-1 transmission, but nonnucleoside reverse transcription (NNRTI) resistance mutations can emerge. Population sequencing among 32 subtype C HIV-1-infected, SD NVP-exposed Zimbawean women demonstrated NNRTI resistance in 2532 (78) women 2330 (77) at 2 weeks, 1131 (35) at 8 weeks, and 527 (19) at 24 weeks. A total of 447 unique TA clones (median 28 per time point), from four women with resistance at 8 weeks but wild-type virus by population sequence at 24 weeks, identified NNRTI mutations in a median of 76 (range 55–96) of individual clones at 2 weeks, 48 (range 33–80) at 8 weeks, and 5 (range 0–15) by 24 weeks. NNRTI mutations in breast milk clones at 2 and weeks from one woman varied significantly from plasma. Population sequencing underestimates the diversity of NNRTI resistance mutations within minority populations following SD NVP in subtype C HIV-1 viral RNA in plasma and breast milk. [ABSTRACT FROM AUTHOR] |
| Databáze: |
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