Bioinformatics Challenges and Opportunities.

Autor: Sharda, Ramesh, Voß, Stefan, Chen, Hsinchun, Fuller, Sherrilynne S., Friedman, Carol, Hersh, William, Tarczy-Hornoch, Peter, Minie, Mark
Zdroj: Medical Informatics; 2005, p63-94, 32p
Abstrakt: As biomedical research and healthcare continue to progress in the genomic/post genomic era a number of important challenges and opportunities exist in the broad area of biomedical informatics. In the context of this chapter we define bioinformatics as the field that focuses on information, data, and knowledge in the context of biological and biomedical research. The key challenges to bioinformatics essentially all relate to the current flood of raw data, aggregate information, and evolving knowledge arising from the study of the genome and its manifestation. In this chapter we first briefly review the source of this data. We then provide some informatics frameworks for organizing and thinking about challenges and opportunities in bioinformatics. We use then use one informatics framework to illustrate specific challenges from the informatics perspective. As a contrast we provide also an alternate perspective of the challenges and opportunities from the biological point of view. Both perspectives are then illustrated with case studies related to identifying and addressing challenges for bioinformatics in the real world. [ABSTRACT FROM AUTHOR]
Databáze: Supplemental Index