| Autor: |
Zahra Toossi, Harriet Mayanja-Kizza, Stephen D. Lawn, Christina S. Hirsch, L. Davis Lupo, Salvatore T. Butera |
| Zdroj: |
AIDS Research & Human Retroviruses; Jan2007, Vol. 23 Issue 1, p93-100, 8p |
| Abstrakt: |
HIV-1 replication remains elevated in dually infected HIV-1TB subjects at completion of antituberculosis therapy. A viral immunocapture assay was used to examine the cellular origin of HIV-1 within plasma from HIV-1TB subjects at time of diagnosis of pulmonary TB, at end of TB treatment, and 6 months after completion of treatment. Asymptomatic HIV-1-infected subjects without TB (HIV-1C) served as controls. Both activated immature macrophage (CD36+) and CD4 T cell (CD26+) compartments contributed to viral load. Changes in the activation status of either cellular compartment paralleled their contribution to viral load. Levels of HIV-1 originating from activated (HLA-DR+) cells and from CD36+and CD26+mononuclear cells resolved to levels observed in HIV-1C by the end of treatment. HIV-1 isolated by anti-CD3 immunocapture from HIV-1TB patients remained significantly higher than from HIV-1C patients at the end of TB treatment and at 12 months follow-up. Therefore, viral production by lymphocytes extends well beyond the completion of TB treatment. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Supplemental Index |
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