| Autor: |
Pechersky, Alexander V., Semiglazov, Vladimir F., Komyakov, Boris K., Guliev, Bakhman G., Gorelov, Andrey I., Novikov, Andrey I., Pechersky, Viktor I., Simonov, Nikolay N., Gulyaev, Alexey V., Samusenko, Igor A., Vonsky, Maxim S., Mittenberg, Alexey G., Loran, Oleg B. |
| Zdroj: |
Thai Journal of Surgery; Apr-Jun2006, Vol. 27 Issue 2, p93-100, 8p |
| Abstrakt: |
Objectives: To study the disruption of the normal development cycle of cells with androgen receptors by partial androgen deficiency of aging men (PADAM). Materials and Methods: In the current study, 15 patients were held under observation (5 with prostate cancer, 5 with bladder cancer and 5 with rectal cancer). Results: The levels of testosterone in the tissues of the peritumorous zone of the prostate as well as in the tumorous tissue in patients with cancer of the prostate, bladder and rectum were higher than analogous indices in the blood serum. The indices of the histochemical score of androgen (AR) in the peritumorous zone among patients with prostate cancer were higher, than the analogous indices of the control group. Upon research of the peritumorous zone among patients observed groups,expressions of ER, PR, bcl-2, Ki67 and p53 were detected. Conclusions: The results of this study suggest the conclusion that production of testosterone by a whole set of tumors and tissues of the peritumorous zone, which is accompanied by increased proliferative activity and disturbance of the regulation of the cell cycle, is caused by PADAM. The given changes are directed at compensating for testicular deficiency. [ABSTRACT FROM AUTHOR] |
| Databáze: |
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