| Autor: |
Pechersky, A. V., Semiglazov, V. F., Loran, O. B., Mazurov, V. I., Karpischenko, A. I., Nikiforov, A. m., Kalinina, N. M., Drygina, L. B., Davydova, N. I., Skorobogatykh, M. G. |
| Zdroj: |
Thai Journal of Surgery; Apr-Jun2006, Vol. 27 Issue 2, p56-63, 8p |
| Abstrakt: |
Objective: To study the mechanism of development of low-differentiated androgen-resistant prostate cancer Patients and Methods: Fourteen patients with stage 3-4 cancer of the prostate were held under examination. Inspection was carried Out before and 1-month after orchiectomy. Results: One month after orchiectomy all patients showed a significant decrease in levels of testosterone (p <0.005), 5a-dihydrotestosterone, 17β-estradiol (p <0.05) in comparison to initial indicators, while levels of LH and FSH had increased (p <0.001). The reduction of testosterone was accompanied by the increase of prolactin, STH, and estrone (p <0.05). The decrease in the level of testosterone was accompanied by the increase in the levels of insulin, IGF-1 (p <0.05), bFGF (p <0.01), 25-OHVitD3, and Ca++(p <0.05) as well as by a reduction in the levels of βTGF, IL-1β, TNFα (p <0.05), acid phosphatase (p <0.01), alkaline phosphatase (p <0.05) and PSA (p <0.005). Conclusion: After orchiectomy an increase in the level of factors that raised kariomitotic activity was observed, while a decrease in the level of factors regulating the cell cycle and beginning of apoptosis was observed. [ABSTRACT FROM AUTHOR] |
| Databáze: |
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