| Autor: |
Link, T.M., Sell, C.A., Masi, J.N., Phan, C., Newitt, D., Lu, Y., Steinbach, L., Majumdar, S. |
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| Zdroj: |
Osteoarthritis & Cartilage; Jan2006, Vol. 14 Issue 1, p63-70, 8p |
| Abstrakt: |
Summary: Objective: To use receiver operator characteristics (ROC) analysis for assessing the diagnostic performance of three cartilage-specific MR sequences at 1.5 and 3T in detecting cartilage lesions created in porcine knees. Design: Eighty-four cartilage lesions were created in 27 porcine knee specimens at the patella, the medial and lateral femoral and the medial and lateral tibial cartilage. MR imaging was performed using a fat saturated spoiled gradient echo (SPGR) sequence (in plane spatial resolution/slice thickness: 0.20×0.39mm2/1.5mm) and two fat saturated proton density weighted (PDw) sequences (low spatial resolution: 0.31×0.47mm2/3mm and high spatial resolution: 0.20×0.26mm2/2mm). The images were independently analyzed by three radiologists concerning the absence or presence of lesions using a five-level confidence scale. Significances of the differences for the individual sequences were calculated based on comparisons of areas under ROC curves (A Z). Results: The highest A Z-values for all three radiologists were consistently obtained for the SPGR (A Z =0.84) and the high-resolution (hr) PDw (A Z =0.79) sequences at 3T. The corresponding A Z-values at 1.5T were 0.77 and 0.69; the differences between 1.5 and 3T were statistically significant (P <0.05). A Z-values for the low-resolution PDw sequence were lower: 0.59 at 3T and 0.55 at 1.5T and the differences between 1.5 and 3T were not significant. Conclusion: With optimized hr MR sequences diagnostic performance in detecting cartilage lesions was improved at 3T. For a standard, lower spatial resolution PDw sequence no significant differences, however, were found. [Copyright &y& Elsevier] |
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