| Autor: |
Osmanliev, D.P., Joyce, H., Watson, R.A., Pride, N.B. |
| Zdroj: |
Respiratory Medicine; Aug2005, Vol. 99 Issue 8, p1053-1060, 8p |
| Abstrakt: |
Summary: Progression of chronic obstructive pulmonary disease (COPD) has been studied predominantly by following change in forced expiratory volume in 1s (FEV1) which reflects both primary airway disease and associated alveolar disease. Carbon monoxide transfer (T lco) (the product of the transfer coefficient K co and alveolar volume V a) is the only simple, widely available test of alveolar function, but few studies have followed long-term changes in an individual. Seventeen middle-aged men with moderate chronic airflow obstruction (mean FEV1 56% of predicted values) were observed with yearly measurements of FEV1, T lco and K co over a mean of 18.9yr. At the end of follow-up FEV1 had fallen to 29% of predicted values. V a, measured by single breath dilution, fell in each man. K co at recruitment ranged from 41% to 110% predicted and remained >75% predicted in eight men at the end of follow-up supporting a phenotype of COPD with predominant airway disease and little emphysema. Fall in FEV1 was faster (2.03% predicted FEV1/yr) in seven men with low initial K co<75% pred. than in men with initial K co>75% pred. (1.14% predicted FEV1/yr, ). Repeated measurements of CO transfer in an individual should increase the present poor knowledge of the contribution of alveolar disease to the progression of chronic airflow obstruction. [Copyright &y& Elsevier] |
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