| Autor: |
Yun M. Ling, Shaw, Michael H., Ayala, Carol, Coppens, Isabelle, Taylor, Gregory A., Ferguson, David J. P., Yap, George S. |
| Předmět: |
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| Zdroj: |
Journal of Experimental Medicine; 9/4/2006, Vol. 203 Issue 9, p2063-2071, 9p |
| Abstrakt: |
Apicomplexan protozoan pathogens avoid destruction and establish a replicative niche within host cells by forming a nonfusogenic parasitophorous vacuole (PV). Here we present evidence for lysosome-mediated degradation of Toxoplasma gondii after invasion of macrophages activated in vivo. Pathogen elimination was dependent on the interferon γ inducible-p47 GTPase, IGTP, required PI3K activity, and was preceded by PV membrane indentation, vesiculation, disruption, and, surprisingly, stripping of the parasite plasma membrane. Denuded parasites were enveloped in autophagosome-like vacuoles, which ultimately fused with lysosomes. These observations outline a series of mechanisms used by effector cells to redirect the fate of a classically nonfusogenic intracellular pathogen toward a path of immune elimination. [ABSTRACT FROM AUTHOR] |
| Databáze: |
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