| Autor: |
Massberg, Steffen, Konrad, Ildiko, Schürzinger, Katrin, Lorenz, Michael, Schneider, Simon, Zohlnhoefer, Dietlind, Hoppe, Katharina, Schiemann, Matthias, Kennerknecht, Elisabeth, Sauer, Susanne, Schulz, Christian, Kerstan, Sandra, Rudelius, Martina, Seidl, Stefan, Sorge, Falko, Langer, Harald, Peluso, Mario, Goyal, Pankaj, Vestweber, Dietmar, Emambokus, Nikla R. |
| Předmět: |
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| Zdroj: |
Journal of Experimental Medicine; 5/15/2006, Vol. 203 Issue 5, p1221-1233, 13p |
| Abstrakt: |
The accumulation of smooth muscle and endothelial cells is essential for remodeling and repair of injured blood vessel walls. Bone marrow-derived progenitor cells have been implicated in vascular repair and remodeling; however, the mechanisms underlying their recruitment to the site of injury remain elusive. Here, using real-time in vivo fluorescence microscopy, we show that platelets provide the critical signal that recruits CD34+ bone marrow cells and c-Kit+ Sca-1+ Lin- bone marrow-derived progenitor cells to sites of vascular injury. Correspondingly, specific inhibition of platelet adhesion virtually abrogated the accumulation of both CD34+ and c-Kit+ Sca-1+ Lin- bone marrow-derived progenitor cells at sites of endothelial disruption. Binding of bone marrow cells to platelets involves both P-selectin and GPllb integrin on platelets. Unexpectedly, we found that activated platelets secrete the chemokine SDF-1α, thereby supporting further primary adhesion and migration of progenitor cells. These findings establish the platelet as a major player in the initiation of vascular remodeling, a process of fundamental importance for vascular repair and pathological remodeling after vascular injury. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Supplemental Index |
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