| Autor: |
KWEE, SANDI A., COEL, MARC N., LIM, JOHN, KO, JEHOON P. |
| Předmět: |
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| Zdroj: |
Journal of Urology; Jan2005, Vol. 173 Issue 1, p252-255, 4p |
| Abstrakt: |
ABSTRACT: Purpose: We evaluated positron emission tomography (PET) with 18fluorine fluorocholine (18F FCH) for the pretreatment localization of prostate cancer. Materials and Methods: A total of 17 patients with prostate cancer who had not yet received treatment for the disease underwent whole body PET following intravenous administration of 3.3 to 4 MBq/kg 18F FCH. PET findings were compared with the results of prostate sextant biopsy and other imaging studies, and the clinical course. Tracer uptake in prostate sextants was measured as a maximum standardized uptake value (SUVmax) and evaluated as a predictor of the prostate sextant biopsy result by ROC analysis. Results: Prostate sextants positive for malignancy on biopsy demonstrated significantly higher SUVmax than biopsy negative sextants (mean 5.5 vs 3.3, p <0.001). In all 6 cases in which biopsy identified malignancy on only 1 side of the prostate it was possible to identify correctly the affected side based on higher SUVmax. Area under the ROC curve for SUVmax as a discriminator of biopsy positive sextants was 0.86. In 2 patients PET demonstrated areas of abnormal uptake in the retroperitoneum. Computerized tomography confirmed the presence of retroperitoneal lymphadenopathy in these areas. In the 2 patients these lesions regressed following hormonal treatment for prostate cancer. Conclusions: Malignant tumors in the prostate gland can be localized based on a standardized regional measurement of 18F FCH uptake. PET with 18F FCH is potentially useful for staging and localizing prostate cancer. [Copyright &y& Elsevier] |
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