Intestinal Oxalate Absorption is Higher in Idiopathic Calcium Oxalate Stone Formers Than in Healthy Controls: Measurements With the [13C2]Oxalate Absorption Test.

Autor: Voss, Susanne, Hesse, Albrecht, Zimmermann, Diana J., Sauerbruch, Tilman, von Unruh, Gerd E.
Předmět:
Zdroj: Journal of Urology; May2006, Vol. 175 Issue 5, p1711-1715, 5p
Abstrakt: Purpose: We assessed the importance of oxalate hyperabsorption for idiopathic calcium oxalate urolithiasis, oxalate absorption in healthy volunteers and recurrent calcium oxalate stone formers was compared. Materials and Methods: The [13C2]oxalate absorption test, a standardized, radioactivity-free test, was performed. On 2 days 24-hour urine was collected and an identical standard diet containing 800 mg Ca daily was maintained. On the morning of day 2 a capsule containing 0.37 mmol sodium [13C2]oxalate was ingested. A total of 120 healthy volunteers (60 women and 60 men) and 120 patients (30 women and 90 men) with idiopathic CaOx urolithiasis (60% or greater CaOx) were tested. Results: Mean intestinal oxalate absorption in the volunteers was 8.0 ± 4.4%, and in the patients was 10.2 ± 5.2% (p <0.001). There was no significant difference in mean absorption values between men and women within both groups. A high overlap between the absorption values of volunteers and patients was found. Only in the patient group did absorption values greater than 20% occur. Oxalate absorption correlated with oxalate excretion in the patients, r = 0.529 (p <0.01) and in the volunteers, r = 0.307 (p <0.01). Conclusions: In high oxalate absorbers dietary oxalate has a significant role in oxalate excretion and, therefore, increases the risk of calcium oxalate stone formation. [Copyright &y& Elsevier]
Databáze: Supplemental Index