| Autor: |
MULUH, E. K., IZUAGBE, G. O., OHIOLE, I. M., DAUDA, M. B., ANTHONY, W. O. |
| Zdroj: |
Journal of Applied Sciences & Environmental Management; 2024 Supplement, Vol. 28, p3883-3894, 12p |
| Abstrakt: |
The objective of this paper was to synthesize and characterize cobalt (II) complexes of 2-{[(2 hydroxy-5-nitrophenyl)methylidene]amino} nicotinic acid derived from o-phenylenediamine and 5- nitrosalicaldehyde using FTIR, 1HNMR, 13CNMR, GCMS and screened to establish their potential as antimicrobial agents, compared with standards Ampiclox for bacteria and ketoconazole for fungal infections. Antimicrobial activity screening of the Schiff base exhibited biological activity virtually against all forms of bacteria andfungi isolates with the B. subtilis and E coli having same minimum inhibition concentrations of 1.8mm each and with the exception of Candidas albicans which exhibited zero diameter zone of inhibition. In this study, it was found that the synthesized Schiff bases exhibited two digits purity range, implying that they were relatively stable. Furthermore, the in silico molecular docking analysis of the Scihff bases is incorporated to predict their binding affinity to established molecular targets in C. albicans, S. aureus, and E. coli. The findings posited that the binding affinity of the Schiff base (9.3 kJ mol-1) is better than that of both the complex (9.0 kJ mol-1) and even the standard drugs (7.6 and 7.9 kJ mol-1) respectively. This lends credence to the Schiff Base as a better pharmaceutical than the present drug in usage, hence the need to harness them for daily use by pharmacies. [ABSTRACT FROM AUTHOR] |
| Databáze: |
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