| Abstrakt: |
Multiple sclerosis is a complex, autoimmune disease of the central nervous system that predominantly affects young adults. Genetic factors play a significant role in an individual's susceptibility to developing MS, but the specific genes involved are not yet fully understood, especially in non-Western populations like Bahrain. Gene expression profiles based on the transcriptome of peripheral blood mononuclear cells from a total of 88 samples from 12 multiple sclerosis patients and 12 control subjects were analyzed. Further analysis was performed by ELISA which included 80 MS patients and 80 control subjects. The study showed a considerable 5 expressed significant genes (TNF-AIP6, IL-1RA, OASL, CLC, and DOCK4), with one gene IL-1RA had been strongly associated with MS patients. Further analysis by ELISA showed that 83 MS patients had positive serum levels of OASL, 87 MS patients had positive serum levels of IL-1RA, and none of the 88 MS patients showed detectable serum levels of CLC and DOCK4. The study showed two significant novel genes CLC and DOCK4 were expressed. Also, it showed considerable significant gene IL-1RA associated with MS. [ABSTRACT FROM AUTHOR] |
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