| Abstrakt: |
BACKGROUND: Cytochrome-P450 eicosanoids from arachidonic acid, including vasodilator epoxyeicosatrienoic acids (EETs) and the vasoconstrictor 20-HETE, are important in regulating blood pressure, vascular tone, and cardiac and renal function. This study examined plasma 20-HETE and EETs in relation to blood pressure and vascular stiffness in a cohort of 1054 community-dwelling young adults from the Raine Study at 27 years. METHODS: Plasma 20-HETE, EETs, and their hydroxylated products were measured by liquid chromatography-tandem mass spectrometry. Pulse wave velocity and aortic distensibility were measured to assess vascular stiffness. Sex differences were assessed using univariate analysis. Multiple regression models assessed the relationship between 20-HETE and systolic blood pressure (SBP) and measures of vascular stiffness. RESULTS: The regression model for SBP showed a positive relationship with plasma 20-HETE (β, 0.092; P <0.0001), after adjusting for sex (P <0.0001), body mass index (P <0.0001), (ln)triglycerides (P <0.0001), and (ln)Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) (P =0.015), and accounted for 29% of the variance in SBP. 20-HETE was positively related to pulse wave velocity (β, 0.059; P =0.021); after adjusting for sex (P <0.0001), SBP (P <0.0001), (ln)triglycerides (P =0.014), (ln)HOMA-IR (P =0.0001), (ln)high-sensitivity C-reactive protein (P =0.005), and age (P =0.002), the model accounted for 34% of the variance in pulse wave velocity. 20-HETE was inversely associated with aortic distensibility (β, −0.051; P =0.029), independent of sex (P <0.0001), SBP (P <0.0001), and (ln)HOMA-IR (P <0.0001); the model accounted for 25% of the variance in aortic distensibility. Plasma EETs were not significant predictors of SBP or vascular stiffness. CONCLUSIONS: In young adults, 20-HETE may play a fundamental role in regulating blood pressure and vascular stiffness independent of numerous cardiometabolic risk factors and cytochrome 450-derived EETs. REGISTRATION: URL: https://www.anzctr.org.au; Unique identifier: CTRN12617001599369. [ABSTRACT FROM AUTHOR] |
