| Autor: |
Thomas, Kelsey R., Bangen, Katherine J., Rotblatt, Lindsay J., Weigand, Alexandra J., Edwards, Lauren, Tosun, Duygu, Galasko, Douglas |
| Zdroj: |
Alzheimer's & Dementia: The Journal of the Alzheimer's Association; Nov2024, Vol. 20 Issue 11, p7777-7787, 11p |
| Abstrakt: |
INTRODUCTION: Subjective cognitive decline (SCD) may be an early marker of Alzheimer's disease (AD) pathology. Until recently, it was impossible to measure biomarkers specific for α‐synuclein pathology; therefore, its association with subjective reports of cognitive decline is unknown. METHODS: Alzheimer's Disease Neuroimaging Initiative participants without dementia (n = 918) were classified as positive or negative for amyloid beta (Aβ+ or Aβ−) and α‐synuclein (α‐syn+ or α‐syn−) biomarkers. Self‐ and study partner–reported cognitive decline was measured with the Everyday Cognition (ECog) questionnaire. RESULTS: Per self‐report, Aβ+/α‐syn+ had the greatest cognitive decline. Aβ−/α‐syn+ did not differ from Aβ−/α‐syn− across ECog scores. Study partner–reported results had a similar pattern, but Aβ+/α‐syn− and Aβ+/α‐syn+ did not differ across ECog scores. Mild cognitive impairment classification moderated the study partner–reported memory score. DISCUSSION: While α‐syn+ alone did not increase subjective reports of cognitive decline, Aβ+/α‐syn+ had the most self‐ and study partner–rated cognitive decline. Therefore, the presence of multiple pathologies was associated with greater SCD. Highlights: Cerebrospinal fluid α‐synuclein (α‐syn) seed amplification assay was used to determine α‐syn positivity.Amyloid beta (Aβ)−/α‐syn−, Aβ−/α‐syn+, Aβ+/α‐syn−, and Aβ+/α‐syn+ biomarker groups were created.Aβ+/α‐syn+ had greater subjective cognitive decline (SCD) than the other biomarker groups.Aβ−/α‐syn+ did not differ from Aβ−/α‐syn− across self‐ or study–partner reported SCD scores.Study partner–reported subjective memory results were largely driven by participants with mild cognitive impairment. [ABSTRACT FROM AUTHOR] |
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