| Autor: |
Takumi TSURUTA, Naoki MATSUMURA, Keijiro MIZUKAMI, Yuko GOTO-KOSHINO, Tomomi AOI, Ryoko YAMADA, Itsuma NAGAO, Megumi SAKAMOTO, Taisuke NAKAGAWA, Ray FUKUOKA, Aki OHMI, CHAMBERS, James K., Kazuyuki UCHIDA, Yukihide MOMOZAWA, Hirotaka TOMIYASU |
| Předmět: |
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| Zdroj: |
Journal of Veterinary Medical Science; 2024, Vol. 86 Issue 10, p1052-1055, 4p |
| Abstrakt: |
Canine gastrointestinal lymphoma is known to be of T-cell origin in most cases, but the molecular biological aberrations have not been clarified. In human intestinal T-cell lymphoma, the mutations in the genes associated with Janus kinase/signal transducer and activator of transcription (JAK-STAT) pathway have been frequently observed. In this study, the gene mutations were investigated in 31 dogs with large cell gastrointestinal lymphoma (LCGIL) by focusing on the genes involved in JAK-STAT pathway. Next-generation sequencing analysis to examine the mutations in STAT3, STAT5B, and JAK1 genes throughout the exon regions revealed the mutations in STAT3 gene in two dogs and JAK1 gene in one dog. In conclusion, this study could not indicate the associations of gene mutations in JAK-STAT pathway with LCGIL in most canine cases. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Supplemental Index |
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