Adult sickle cell disease and SARS-CoV-2: an increasingly common comorbidity for a rare disease.

Autor: Boggan, Michaela, Edwards, Christopher L., Meek, Jordan, Wood, Mary, Bryson, W. Jeff, Sollers, John J., Parker, Debra O., Barker, Camela S., Miller, Jessica, Downey, Brianna, Lockett, Asha, Rosales, Jazmin, Munroe Jr., Courtney, Wax, Noa, Scott, Sharena, Pittman, Bridget, Turner, Merell, Dietahin, Hillary T., Smith, Eric, McDougald, Alexandria
Zdroj: Italian Journal of Medicine; 2024, Vol. 18 Issue 3, p1-7, 7p
Abstrakt: Sickle cell disease (SCD) is a collection of genetic lesions that manifest in the diminished effectiveness of hemoglobin. We collected and reviewed the recent and extant literature on SARS-CoV-2 (COVID-19) and SCD. We posit an answer to the question associated with any adaptive responses to COVID-19 in individuals with SCD. We collected papers from MEDLINE and all available published papers on COVID-19 and SCD. Unlike a formal meta-analysis, given the early phase of this review in the pandemic, we did not seek unpublished papers. We found an emerging literature where case studies dominated, and traditional large N epidemiological studies were absent. Patients with SCD share many comorbid illnesses with an increased risk of mortality associated with contracting COVID-19. There is sufficient empirical justification to accelerate research on the impact of a viral pathogen like COVID-19 on individuals with SCD. [ABSTRACT FROM AUTHOR]
Databáze: Supplemental Index