| Abstrakt: |
Fat-suppression T2-weighted imaging (FS-T2WI), one of the key sequences in MRI, can clearly distinguish edema in the tumor surrounding environment. Peritumoral edema was a predictor for triple negative breast cancer (BC) and was related to Luminal A-like BC. However, there is currently limited research on the significance between different types of edema and molecular subtypes. This study aimed to explore the relationship between focal edema (including no edema, peritumoral edema, prepectoral edema, subcutaneous edema) and molecular subtypes. Atotal of 206 women diagnosed with invasive BC were retrospectively enrolled and underwent MR scanning on a 3.0 T scanner. 34 were Luminal A-like, Luminal B-like [37 human epidermal growth factor receptor 2 (HER2)-positive and 51 HER2-negative], 53 HER2 overexpression, and 31 basal-like. Focal edema was defined on FS-T2WI. The comparison of classification variables was executed using chi-square or Fisher exact test. The rate of no edema in Luminal A-like was higher than that of Luminal B-like HER2 + and HER2 overexpression (P = 0.002, P < 0.001). The peritumoral and subcutaneous edema rates of Luminal A-like were lower than those of HER2 overexpression (P = 0.043, P = 0.021). The rate of no edema in Luminal B-like HER2 - and basal-like were higher than Luminal B HER2 + (P = 0.001, P = 0.025), as well as HER2 overexpression (P < 0.001, P < 0.001). The subcutaneous edema rate of Luminal B HER2 - was lower than that of HER2 overexpressing, P = 0.002. Luminal A-like had a higher rate of no edema, while the rates of peritumoral edema and subcutaneous edema were lower. Luminal B-like HER2 + and HER2 overexpression (both HER2 statuses were positive) exhibited lower rate of no edema, higher rates of peritumoral edema and subcutaneous edema. [ABSTRACT FROM AUTHOR] |
