| Abstrakt: |
A recent report from Radboud University Medical Center discusses research on enzymes and coenzymes. The study focuses on Cryptococcal meningitis, a high-mortality infection, and the use of 5-fluorocytosine (5-FC) in its treatment. The researchers conducted whole-genome sequencing and proteomic analyses on C. neoformans isolates with varying 5-FC susceptibility. They found that mutations in genes of the pyrimidine salvage pathway are responsible for 5-FC resistance. Understanding these mutations and resistance development is crucial for improving patient outcomes. [Extracted from the article] |
