| Autor: |
WANG, Sibei, LIU, Yuhui, LIANG, Yue, XI, Yaru, ZHAI, Yupeng, LEE, Dongho, XU, Jing, GUO, Yuanqiang |
| Zdroj: |
Chinese Journal of Natural Medicines; Sep2024, Vol. 22 Issue 9, p842-853, 12p |
| Abstrakt: |
Eight novel clerodane diterpenoids (1 − 8) were isolated from the twigs of Casearia graveolens. Their structures were elucidated through comprehensive nuclear magnetic resonance (NMR), high-resolution electrospray ionization mass spectrometry (HR-ESI-MS), and electronic circular dichroism (ECD) analyses. In addition to structural determination, surface plasmon resonance (SPR) assays were conducted to investigate molecular interactions, revealing that compound 8 exhibited high affinity for vascular endothelial growth factor receptor 2 (VEGFR2), a key regulator of tumor angiogenesis. Subsequent in vivo experiments demonstrated that compound 8 effectively inhibited angiogenesis and displayed significant antitumor activity by suppressing tumor proliferation and metastasis in zebrafish xenograft models. These findings suggest that compound 8 holds promise as an anticancer lead compound targeting VEGFR-2 to obstruct tumor angiogenesis. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Supplemental Index |
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