| Autor: |
Hongjie Fan, Xuancheng Xie, Zhenzhu Pang, Licai Zhang, Rong Ding, Cheng Wan, Xinghai Li, Zebin Yang, Jihong Sun, Xuefeng Kan, Bufu Tang, Chuansheng Zheng |
| Zdroj: |
International Journal of Surgery; Jan2024, Vol. 110 Issue 1, p261-269, 9p |
| Abstrakt: |
Purpose: To evaluate the risk of pneumothorax in the percutaneous image-guided thermal ablation (IGTA) treatment of colorectal lung metastases (CRLM). Methods: Data regarding patients with CRLM treated with IGTA from five medical institutions in China from 2016 to 2023 were reviewed retrospectively. Pneumothorax and non-pneumothorax were compared using the Student's t-test, χ² test and Fisher's exact test. Univariate logistic regression analysis was conducted to identify potential risk factors, followed by multivariate logistic regression analysis to evaluate the predictors of pneumothorax. Interactions between variables were examined and used for model construction. Receiver operating characteristic curves and nomograms were generated to assess the performance of the model. Results: A total of 254 patients with 376 CRLM underwent 299 ablation sessions. The incidence of pneumothorax was 45.5%. The adjusted multivariate logistic regression model, incorporating interaction terms, revealed that tumour number [odds ratio (OR) =8.34 (95% CI: 1.37-50.64)], puncture depth [OR =0.53 (95% CI: 0.31-0.91)], pre-procedure radiotherapy [OR= 3.66 (95% CI: 1.17-11.40)], peribronchial tumour [OR =2.32 (95% CI: 1.04-5.15)], and emphysema [OR =56.83 (95% CI: 8.42-383.57)] were significant predictive factors of pneumothorax (all P<0.05). The generated nomogram model demonstrated a significant prediction performance, with an area under the receiver operating characteristic curve of 0.800 (95% CI: 0.751-0.850). Conclusions: Pre-procedure radiotherapy, tumour number, peribronchial tumour, and emphysema were identified as risk factors for pneumothorax in the treatment of CRLM using percutaneous IGTA. Puncture depthwas found to be a protective factor against pneumothorax. [ABSTRACT FROM AUTHOR] |
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