| Abstrakt: |
Purpose: This study aims to investigate the response of exerkines in the liver, adipose tissue, and skeletal muscle to acute exercise under different environmental temperatures. Methods: Male C57/BL6N mice were subjected to acute exercise in low-temperature (4 °C, CE), room temperature (21 °C, RE), and thermoneutral environment (32 °C, TE) . Immediately after exercise, visceral adipose, liver, and tibialis anterior muscle tissues were collected to examine the mRNA expression of exerkines. Results: In the liver, acute exercise upregulated the expression of gdf15, independent of environmental temperature. In the low-temperature environment, exercise increased the expression of fgf-21 expression in the liver. In the thermoneutral environment, acute exercise increased apelin expression in the liver. In skeletal muscle, acute exercise upregulated fgf-21 expression, independent of environmental temperature. In adipose tissue, acute exercise in the low-temperature environment downregulated the expression of irisin, spexin, and upregulated adipolin. In the room temperature environment, acute exercise upregulated adipose tissue metrnl and spexin expression. In the thermoneutral environment, acute exercise increased leptin expression in adipose tissue. Conclusion: The environmental temperature during exercise affects the expression of fgf-21, apelin, adipolin, metrnl, and leptin mRNA. It should be considered in the design of exercise programs and personalized exercise guidance to optimize the expression of specific exerkines by adjusting the environmental temperature during exercise. [ABSTRACT FROM AUTHOR] |
