Autor: |
Katsuya, Shohei, Kawata, Yoshikazu, Sugimoto, Masayuki, Nishimura, Taku, Tsubota, Jun |
Předmět: |
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Zdroj: |
Bioscience, Biotechnology & Biochemistry; Sep2024, Vol. 88 Issue 9, p1073-1080, 8p |
Abstrakt: |
The use of halophilic bacteria in industrial chemical and food production has received great interest because of the unique properties of these bacteria; however, their safety remains under investigation. Halomonas sp. KM-1 intracellularly stores poly-D-β-hydroxybutyric acid under aerobic conditions and successively secretes D-β-hydroxybutyric acid (D-BHB) under microaerobic conditions. Therefore, we tested the safety of Halomonas sp. KM-1-derived D-BHB and the impurities generated during D-BHB manufacturing at a 100-fold increased concentration in acute tests using mice and daily intake of 16.0 g D-BHB in Japanese adults for 12 weeks. In the mice test, there were no abnormalities in the body weights or health of mice fed the purified D-BHB or its impurities. In the Japanese adult test, blood parameters and body condition showed no medically problematic fluctuations. These findings indicate that Halomonas sp. KM-1 is safe and can be used for commercial production of D-BHB and its derivatives. [ABSTRACT FROM AUTHOR] |
Databáze: |
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