| Autor: |
Hayashi, Jun‐ichiro, Ono, Kohta, Iwamura, Yuki, Sasaki, Yasuyuki, Ohno, Tasuku, Goto, Ryoma, Nishida, Eisaku, Yamamoto, Genta, Kikuchi, Takeshi, Higuchi, Naoya, Mitani, Akio, Fukuda, Mitsuo |
| Zdroj: |
Journal of Periodontology; Aug2024, Vol. 95 Issue 8, p718-728, 11p |
| Abstrakt: |
Background: Antimicrobial photodynamic therapy (aPDT) is an effective method for eradicating bacteria in periodontal therapy. Standard aPDT requires the insertion of a laser tip into a periodontal pocket, in which the direction of irradiation is limited. Therefore, we devised an aPDT method that uses a transgingival near‐infrared wavelength and indocyanine green‐encapsulated and chitosan‐coated nanoparticles as a photosensitizer. Methods: Forty patients undergoing supportive periodontal therapy, who had a single root tooth with a pocket of 5 mm or deeper, were used as subjects. In the test group, aPDT was performed by laser irradiation from outside the gingiva using photosensitizer nanoparticles. In the control group, pseudo aPDT without photosensitizer was performed by transgingival irradiation. Subgingival plaque was sampled from inside the pocket before, immediately after, and 1 week after treatment, and evaluated by colony counting and real‐time polymerase chain reaction. Results: There were no significant differences in age, sex, periodontal pocket depth, and bleeding on probing between the test and control groups. Compared with the colony count before treatment, the count in the test group was significantly reduced immediately after treatment. The number of patients with colony reduction to ≤50% and ≤10% was significantly higher in the test group than in the control group. None of the participants reported pain, although one participant reported discomfort. Conclusion: As a bacterial control method for residual pockets in patients undergoing supportive periodontal therapy, transgingival aPDT is a promising treatment strategy that is not generally accompanied by pain or discomfort. [ABSTRACT FROM AUTHOR] |
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