| Autor: |
Tanwar, Himanshi, Gnanasekaran, Jeba Mercy, Allison, Devon, Chuang, Ling-shiang, He, Xuesong, Aimetti, Mario, Baima, Giacomo, Costalonga, Massimo, Cross, Raymond K, Sears, Cynthia, Mehandru, Saurabh, Cho, Judy, Colombel, Jean-Frederic, Raufman, Jean-Pierre, Thumbigere-Math, Vivek |
| Zdroj: |
Journal of Crohn's & Colitis; Aug2024, Vol. 18 Issue 8, p1319-1341, 23p |
| Abstrakt: |
As the opposite ends of the orodigestive tract, the oral cavity and the intestine share anatomical, microbial, and immunological ties that have bidirectional health implications. A growing body of evidence suggests an interconnection between oral pathologies and inflammatory bowel disease [IBD], implying a shift from the traditional concept of independent diseases to a complex, reciprocal cycle. This review outlines the evidence supporting an 'oral–gut' axis, marked by a higher prevalence of periodontitis and other oral conditions in IBD patients and vice versa. We present an in-depth examination of the interconnection between oral pathologies and IBD, highlighting the shared microbiological and immunological pathways, and proposing a 'multi-hit' hypothesis in the pathogenesis of periodontitis-mediated intestinal inflammation. Furthermore, the review underscores the critical need for a collaborative approach between dentists and gastroenterologists to provide holistic oral–systemic healthcare. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
