| Autor: |
Dawidowski, Bartosz, Olejniczak, Barbara, Groblińska, Katarzyna, Knapińska, Magdalena, Kozicka, Urszula, Krasiński, Michał, Kułak, Anna, Grelecki, Grzegorz, Czaplińska, Zuzanna, Piotrowska, Oliwia, Kościelecka, Klaudia, Podwalski, Piotr, Michalczyk, Anna, Samochowiec, Jerzy |
| Zdroj: |
Psychiatria Polska; 2024, Vol. 58 Issue 3, p467-494, 28p |
| Abstrakt: |
Aim. Evidence suggests that decreased dopamine secretion in mesocorticolimbic pathways could predispose to increased susceptibility to substance addiction. It has been proposed to define such a phenomenon as the reward deficiency syndrome (RDS). Dopaminergic projections of the reward system receive glutaminergic projections from the cortex. Research indicates that a reduction in the stimulating glutamatergic transmission on the dopaminergic system could represent an alternative phenotype of RDS. A potential source of this type of abnormality is glutamate reuptake which depends on the function of excitatory amino acid transporter (EAAT) proteins. The most important of them is EAAT2, polymorphisms of which have been linked to several mental disorders. The aim of the presented research was to assess the association of the rs4354668 gene variants for EAAT2 with the risk of substance use disorders. Material and methods. We analyzed the genetic and psychometric data of 125 young adults (n = 125) for the effect of the rs4354668 polymorphism of the SLC1A2 gene for EAAT2 on risky or harmful drug use (RHDU). After exploratory analysis we used logistic regression models to assess the probability of RHDU in individual groups. Results. In the final model the T/T variant of rs4354668 was significantly associated with a lower probability of RHDU occurrence compared to the G/G variant (OR: 0.021; 95% CI: 0.001-0.275; p = 0.009). Other significant predictors of RHDU were smoking status and risky or harmful drinking of alcohol. Conclusions. The results obtained may indicate a possible relationship of the risk of harmful drug use with variants of the rs4354668 polymorphism of the SLC1A2 gene for EAAT2. Subjects with the T/T variant of this polymorphism appear to be less at risk of developing drug use disorders. [ABSTRACT FROM AUTHOR] |
| Databáze: |
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