| Autor: |
Augustina, Eka Fitria, Ismulah, Yenniy, Cristian Panggabean, Michael Salomo |
| Předmět: |
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| Zdroj: |
Journal of International Dental & Medical Research; 2024, Vol. 17 Issue 2, p628-631, 4p |
| Abstrakt: |
Gingivitis is the mildest form of periodontal disease, but if the condition is left untreated, it will develop to a more severe periodontal disease that can damage the supporting tissues of the teeth which can cause inflammation of the periodontal tissues due to the presence of oral microbial biofilms, especially gram-negative anaerobes, such as porphyromonas gingivalis. The curcumin extract administration is able to inhibit and stop the activity of inflammatory mediators produced by bacteria. To determine the effect of 1% curcumin on the number of lymphocytes and the expression of MMP 13 in the gingiva of Wistar rats exposed to P. gingivalis bacteria. Materials and Methods: Wistar rats as gingivitis models, P. gingivalis bacteria that have been grown in TBS media previously, 1 g of curcumin that was mixed with Corn oil to a volume of 100 ml to form a suspension of curcumin with a concentration of 1%. This study used an in vivo laboratory experimental method using experimental Wistar rats which criteria had been determined and were divided into 5 treatment groups. In this study, curcumin was effective in reducing the number of lymphocytes and MMP 13 in gingivitis. Conclusion: Prolonged exposure to Pg can affect the increase in the number of lymphocytes and the expression of MMP 13, but with the administration of 1% curcumin, it was seen that there was a decrease in the number of lymphocytes and the expression of MMP13. [ABSTRACT FROM AUTHOR] |
| Databáze: |
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