| Abstrakt: |
One of the most common cancers in the world is oral squamous cell carcinoma. Increasing apoptotic activity is one method of treating cancer by reducing or stopping the uncontrolled growth of cancer cells. Known for its many health advantages and anti-tumor capabilities, Ant's Nest (Myrmecodia pendans) is a native of Papua, Indonesia. This study aimed to analyze the therapeutic effects of Ant's Nest extract on epithelial dysplasia in a carcinoma model through the immunoexpression of Caspase-3, Bax, and Bcl-2. The research was a pure experimental study using male Sprague Dawley rats, divided into control and treatment groups. The experimental animals were induced with 0.5% dimethylbenz(a)anthracene (DMBA) for 4 weeks, resulting in epithelial dysplasia. Subsequently, Ant's Nest water and ethanol extracts were administered orally at a dose of 6.3 mg dissolved in 0.5% CMC once a day for 4 weeks. Immunohistochemical examinations were conducted for Caspase-3, Bax, and Bcl-2 immunoexpression. The results of the study showed that there were notable variations in the immunoexpression of Bcl-2, Bax, and Caspase-3 between the treatment and control groups. The group that was given Ant's Nest water and ethanol extracts showed a decrease in Bcl-2 immunoexpression and an increase in Caspase-3 and Bax immunoexpression. We find that via modulating the immunoexpression of Caspase-3, Bax, and Bcl-2, Ant's Nest extract treatment promotes the process of apoptosis. [ABSTRACT FROM AUTHOR] |
