Repeated extrinsic and anisotropic mechanical inputs promote polarized adherens junction elongation.

Zdroj: Health & Medicine Week; 2024, p4007-4007, 1p
Abstrakt: According to a preprint abstract from biorxiv.org, researchers have investigated how muscles located under the epidermis stimulate the extension of anterior-posterior (AP-oriented) epidermal adherens junctions during late C. elegans embryonic elongation. The study found that asynchronous patterns of muscle contractions drive embryo rotations, and the junctions between the lateral and dorso-ventral epidermis repeatedly oscillate between a folded and extended state. The researchers also discovered that muscle contractions stimulate E-cadherin turnover, and enhanced accumulation of E-cadherin along AP-oriented junctions lowers their line tension and promotes their elongation. This research has not yet undergone peer review. [Extracted from the article]
Databáze: Supplemental Index