Ameloblastic Fibrodentinoma: A Case Series.

Autor: Mesil, Dr. Kedkanya, Bautista, Dr. Melissa Mejia, Kozakewichc, Prof. Harry, Cuevas-Nunez, Dr. Maria, Woo, Prof. Sook-Bin
Zdroj: Oral Surgery, Oral Medicine, Oral Pathology & Oral Radiology; Aug2024, Vol. 138 Issue 2, pe63-e63, 1p
Abstrakt: Ameloblastic fibrodentinoma (AFD) is a benign mixed epithelial and mesenchymal odontogenic tumor that some believe represents a developing odontoma, although the concept of progressive maturation from AFD to odontoma is controversial. The objective of this study is to characterize the clinical and histopathological features of a series of AFD to improve our understanding on this lesion. Eight cases of AFD were identified from the archives of StrataDx Inc. and Boston Children's Hospital Department of Pathology from 2005 to 2023. Clinical data and histopathologic features were evaluated. There were 8 biopsies from 8 patients with M:F of 1.6:1. The median age was 10.5 years (range 3-18 years) and maxilla and mandible were equally affected. All cases were radiolucencies with or without radiopacities. Seven of the 8 cases were associated with unerupted teeth, and one case was in place of the right mandibular third molar. AFD exhibited a vaguely lobular architecture. In many areas, there was a cellular proliferation of plump, spindled and stellate cells within myxoid stroma similar to the stroma of ameloblastic fibroma although some areas were hypocellular. All cases showed areas of classic follicular ameloblastoma with stellate reticulum-like areas and palisading of basal cell nuclei, although islands and cords of odontogenic epithelium either composed of basaloid cells or resembling rests were also present in 75% of cases. Dentinoid with enclaved odontogenic epithelium were identified in all cases and BRAF was negative in 3 of 3 cases. None of the cases showed enamel matrix, tubular dentine or other dental hard tissues. AFD occurs in the first two decades of life associated with unerupted teeth, and resembles ameloblastic fibroma with dentinoid formation but without other evidence of dental hard tissue formation and is unlikely to represent a developing odontoma. [ABSTRACT FROM AUTHOR]
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