| Abstrakt: |
This article discusses an improved method for sampling and analyzing cerebrospinal fluid (CSF) in mice. The researchers developed a technique that allows for the collection of larger volumes of pure CSF from individual mice, enabling multiple protein analytical assays from a single sample. They also established a quality control workflow to ensure cell- and blood-free CSF. Using this method, they found that the CSF proteome remains stable over time in wild-type mice, but is significantly altered in a mouse model of Alzheimer's disease. This research has the potential to advance biomedical applications in the study of CSF proteins. [Extracted from the article] |
