| Autor: |
Huaping Lei, Yachao Jiang, Jinhua Liu, Youliang Guan, Songquan Song, Cuifang Tang, Sitian Fei, Hui Zhang |
| Zdroj: |
Pakistan Journal of Pharmaceutical Sciences; 2024 Special Issue, Vol. 37, p235-243, 9p |
| Abstrakt: |
Stimulus-responsive mesoporous silica nanoparticles (MSNs) have displayed great potentiality for controlledrelease and targeted drug delivery. In the current work, a supercritical fluid method was utilized to successfully prepare cinnamon oil loaded into chitosan grafted MSNs (CO@CS-MSNs). The influencing factors of drug loads, such as pressure, temperature, impregnation time and depressure time, were investigated. The structure of CO@CS-MSNs was demonstrated with Fourier-transform infrared (FT-IR) spectroscopy, transmission electron microscope (TEM), scanning electron microscopy (SEM), thermogravimetry (TG) as well as X-ray diffraction (XRD). The drug release assays in vitro at various pH conditions displayed that CO@CS-MSNs had an excellent pH-responsive release behavior, which confirmed that CO was loaded successfully into the CO@CS-MSNs. The findings indicated that the supercritical fluid approach is a non-destructive and efficient approach for stimulus-responsive MSNs, which is expected to further expand its application range. [ABSTRACT FROM AUTHOR] |
| Databáze: |
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